Effect of norethindrone combined with mifepristone in the treatment of menopausal dysfunctional uterine bleeding

Abstract

Objective To explore the effect of norethindrone combined with mifepristone in the treatment of menopausal transition period of functional uterine bleeding. Methods A total of 100 patients with dysfunctional uterine bleeding after menopause were selected.The patients were randomly divided into two groups by computer, 50 patients in each group, the control group and the observation group were treated with norethindrone and norethisterone combined with mifepristone. Results The endometrial thickness [(5.69±1.57)mm], incidence rate of adverse event (2.00%), recurrent bleeding (0.00%), total effective rate (98.00%), FSH[(6.48±1.47)IU/L], LH[(8.24±2.65)IU/L], P[(1.32±0.12)nmol/L] and E2[(152.48±2.51)pmol/L] in the observation group were significantly better than those in the control group [(10.35±1.85)mm, 24.00%, 18.00%, 70.00%, (9.65±2.85)IU/L, (6.41±1.05)IU/L, (3.41±1.69)nmol/L, (405.36±8.95)pmol/L, t=13.580, χ2=10.698, χ2=9.890, χ2=14.583, t=6.990, t=4.539, t=8.722, t=192.369, all P<0.05). Conclusion Norethindrone combined with mifepristone in the treatment of menopausal transition dysfunctional uterine bleeding patients has significant effect. Key words: Uterine hemorrhege; Norethindrone; Mifepristone