The influence of mifepristone combined with Mirena on endometrial thickness and hemoglobin in perimenopausal women with dysfunctional uterine bleeding

Abstract

Objective To analyze the influence of mifepristone combined with Mirena on endometrial thickness and hemoglobin in perimenopausal women with dysfunctional uterine bleeding, and to provide the basis for clinical treatment of dysfunctional uterine bleeding. Methods 66 perimenopausal women with dysfunctional uterine bleeding in department of gynaecology of our hospital from October 2012 to October 2014 were selected and divided into two groups according to the random number table method. 33 cases in control group received the treatment of mifepristone, and 33 cases in research group received the treatment of mifepristone combined with Mirena. After 12 months’ follow-up, the menstrual blood volume, endometrial thickness, and blood hemoglobin level were compared before and after treatment, and adverse reactions and recurrence rate were observed during treatment and follow-up. Results ①PBCA score of both two groups decreased after treatment, that of study group decreased more significantly (P<0.05); ②the endometrium of both two groups became thinner after treatment, that of study group was much thinner (P<0.05); ③the hemoglobin (Hb) level of both two groups increased after treatment, that of study group increased more significantly (P<0.05); ④during the treatment period, there were 2 cases (6.1%) of adverse reactions in study group, and 8 cases (24.2%) in control group, with statistically significant difference between two groups (P<0.05); ⑤during 12 months’ follow-up, there were 1 case (3%) of recurrence in study group, and 6 cases (18.2%) in control group, with statistically significant difference between two groups (P<0.05). Conclusion For patients with perimenopausal dysfunctional uterine bleeding, the treatment method of Mirena combined with mifepristone can improve the symptom of bleeding, increase hemoglobin concentration, reduce the thickness of the endometrium and adverse reactions, so it is worthy of popularization and application. Key words: Mirena; Mifepristone; Climacteric dysfunctional uterine bleeding; Endometrial thickness; Hemoglobin; Menstrual blood volume