Abstract
In this paper, an experimental evidence is provided to investigate the potential of microchannel reactors (MCRs) for uniform particle size distribution (PSD) of curcumin nano-particles via liquid anti-solvent precipitation (LASP) technique. For this purpose, three arrangements of microchannel reactors (MCRs) were designed with 800μm in diameter by 30mm in length in various confluence angles of 45°, 90°, and 135°. The influence of confluence angle was investigated in terms of particle size reduction, short-term, and physical stability. PSD, SEM imaging, XRD, DSC, FTIR, and zeta potential measurements were also employed to characterize the produced nano-suspentions.Upon application of the MCR with confluence angle of 135°, the precipitated particle size was found 181nm, indicating that this geometry of micrormixer can establish higher micromixing efficiency. The superior performance of MCRs with large contact angle and understanding of mixing phenomena was further linked to pressure drop, dissipation rate and size of generated nano-particles under various total liquid flow rates.
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