Effect of magnesium sulfate combined with salbutamol sulfate on lung function in children with acute attack of severe bronchial asthma

Abstract

Objective To investigate the effect of magnesium sulfate combined with salbutamol sulfate on lung function in children with acute attack of severe bronchial asthma. Methods 60 children with acute attack of severe bronchial asthma admitted into our hospital from January 2015 to June 2016 were randomly divided into observation group and control group, 30 cases in each group. Control group took salbutamol sulfate, and observation group took magnesium sulfate combined with salbutamol sulfate. After treatment for 1 week, the curative effect, recovery indexes (wheeze, short of breath, cough), hospital stay, lung function indexes [peak expiratory flow (PEF), forced expiratory volume in one second (FEV1), forced vital capacity (FVC)], and adverse reactions of two groups were compared. Results The total effective rate of observation group was 96.67%, which was significantly higher than 70.00% of control group (χ2=7.680, P 0.05); after treatment, the levels of FEV1, PEF, FVC in two groups significantly increased, and the increased tendency of observation group was more significant (P 0.05). Conclusion Compared with pure use of salbutamol sulfate for treating acute attack of severe bronchial asthma, magnesium sulfate combined with salbutamol sulfate has more definite curative effect and less adverse reactions, which can improve clinical symptoms and lung function, worthy of further clinical application. Key words: Magnesium sulfate; Salbutamol sulfate; Severe bronchial asthma; Acute attack; Lung function; Children