Effect of salbutamol combined with ipratropium bromide in the treatment of acute asthma attack

Abstract

Objective To study the effect and value of combined treatment with salbutamol and ipratropium bromide in patients with bronchial asthma. Methods Seventy-two patients with acute bronchial asthma who were treated in our hospital were enrolled from June 2016 to June 2017. They were divided into experimental group and reference group by the random number table, 36 cases in each group. The reference group was treated with salbutamol, and the experimental group was treated with salbutamol and ipratropium bromide atomized inhalation. The lung function index, duration of symptom relief, and clinical treatment effect were compared between the two groups. Results There was no statistically significant difference in the duration of wheezing symptoms between the two groups (P>0.05); the duration of cough symptoms, asthma symptoms, and chest tightness in the experimental group were shorter than those in the reference group. The forced expiratory volume in 1 s, forced vital capacity, vital capacity, and peak expiratory flow in the experimental group were higher than those in the reference group. The total effective rate of bronchial asthma in the experimental group was significantly higher than that in the reference group (94.44% vs.75.00%), with statistically significant difference (P<0.05). Conclusion The combination of salbutamol and ipratropium bromide has a significant clinical effect in the treatment of acute asthmatic bronchitis, which can effectively alleviate cough, asthma, chest tightness, and wheezing, should be clinically promoted. Key words: Salbutamol; Ipratropium bromide; Aerosol inhalation; Bronchial asthma; Acute attack