Effect of magnesium sulfate combined with nifedipine on hypertensive disorders in pregnancy

Abstract

Objective To investigate the effect of magnesium sulfate combined with nifedipine on hypertensive disorders of pregnancy (HDCP). Methods Ninety-six patients with HDCP who were treated in the Eighth People’s Hospital of Taiyuan from June 2016 to June 2018 were enrolled. The patients were divided into two groups. Forty-eight patients in the control group were treated with magnesium sulfate alone, and 48 patients in the observation group were treated with magnesium sulfate and nifedipine. The total effective rate, blood pressure levels and renal function indexes, abnormal pregnancy rate were compared between the two groups. Results The therapeutic effective rate was 93.75% in the observation group and 79.17% in the control group, and there was significant difference (P<0.05). After treatment, the SBP, DBP, uric acid, blood urea nitrogen and serum creatinine levels in the observation group were significantly lower than those of the control group (P all<0.05); the abnormal pregnancy rate was 4.17% in the observation group and 16.67% in the control group, and the difference was significant (P<0.05). Conclusions The combination of magnesium sulfate and nifedipine in patients with HDCP can effectively control the blood pressure of patients, improve the therapeutic effect, and reduce the occurrence of abnormal pregnancy. Key words: Magnesium sulfate; Nifedipine; Gestational hypertension