Abstract
Purposes: To determine the effect of Elaeagnus conferta Roxb dry fruit powder (ECR) on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Methods: In a randomized controlled study, acute alcohol intoxication was induced in mice with Hongxing liquor containing 65 % v/v ethanol orally. The effect of ECR on blood alcohol clearance and on the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase in the mice was then investigated. Results: A 30-min pretreatment with ECR at 400 and 800 mg/kg led to a faster clearance of blood alcohol after the alcohol ingestion. The concentration of blood alcohol at 4 h after alcohol ingestion decreased by 21.2 % in mice pretreated with 800 mg/kg ECR. The activities of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were enhanced by ECR. Conclusion: These results suggest that pretreatment with ECR might stimulate the clearance of blood alcohol by increasing the activities of hepatic alcohol dehydrogenase and aldehyde dehydrogenase. Keywords: Elaeagnus conferta Roxb, blood alcohol clearance, alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH).
Highlights
Consumption of alcohol is rapidly increasing these days
The ratio of K/Na is high in E. conferta roxb fruit; this is good for the cardiovascular system [14]
The metabolism of ethanol is mainly performed in liver by hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) [18]
Summary
Consumption of alcohol is rapidly increasing these days. heavy drinking does much harm to human health. The native people in Yunnan province (South China) have been using its dried fruits to relief the aftereffects of alcohol for hundreds of years. The effect of E. conferta Roxb dried fruit on alcohol metabolism has not been studied. The effects of E. conferta Roxb dried fruit powder (ECR) on blood alcohol clearance and on hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities were tested in acute alcohol-treated mice. Thirty minutes prior to alcohol administration, the negative control and the normal control supergroups were given 0.2 mL of 0.5 % CMC-Na, while ECR-L, M and H supergroups were treated with different doses of ECR. To determine hepatic ADH and ALDH activities, 60 Kunming mice were treated as described above and sacrificed at different times after alcohol administration. A value of p < 0.05 was considered statistically significant
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