Abstract
Rat strains raised by genetical selection for either high (AA strain) or low (ANA strain) voluntary ethanol consumption were compared with respect to their hepatic alcohol and aldehyde dehydrogenase activities. Liver alcohol dehydrogenase activity was lower in both sexes in the AA strain compared with the ANA strain. The NAD-dependent aldehyde dehydrogenase activity was higher in the mitochondrial and microsomal fractions and lower in the soluble fraction in the AA strain than in the ANA strain. These differences were more pronounced in females than in males. The NAD-dependent utilization of acetaldehyde in liver homogenates was higher in the AA strain in both sexes, when the initial acetaldehydehyde level was 0·40 mM, but there was no difference at 0¢13 mM acetaldehyde. It is concluded that the higher activities in the AA strain are due mainly to those aldehyde dehydrogenases of mitochondrial and microsomal fractions, which have K m -values for aldehydes in the millimolar range. The higher alcohol dehydrogenase and lower aldehyde dehydrogenase activity in livers of rats of the ethanol-avoiding ANA strain may contribute to the previously found higher acetaldehyde levels in blood and liver of rats of this strain after ethanol administration.
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