Effect of loop electrosurgical excision procedure on outcome of subsequent fertility and pregnancy

Abstract

Objective To investigate the effects of cervical loop electrosurgical excision procedure (LEEP) to fertility and pregnancy outcome of patients with cervical intraepithelial neoplasia (CIN).Methods 20 inpatients of CIN from January 2009 to August 2011 were given the LEEP treatment,as the observation group,while other 20 healthy pregnant women randomly selected within the same period of the pregnancy out-patient hospital treatment without history of gynecological surgery,were observed as the control group,the observed pregnancy rate and pregnancy outcome were examined.Results The pregnancy rate of the observation group of 20 patients was 85％ (17/20),preguancy rate was 90％ (18/20) in the control group,there was no significant difference (P＞ 0.05).Cesarean section rate of the observation group was significantly higher than that in the control group (P＜0.05),and there was also no significant difference in abortion incidence,incidence of preterm premature,rupture of membranes incidence and the incidence of small for gestational age (SGA) children in two groups(P＞0.05),no neonatal deaths occurred in the patients of two groups.Conclusion LEEP has no significant effect on the fertility of the CIN patients,without increasing the abortion rate,the rate of preterm birth,premature rupture of membranes,and incidence of SGA children. Key words: Loop electrosurgical excision procedure (LEEP); Cervical intraepithelial neoplasia; Fertility; Pregnancy outcome