Current research status of diagnosis and treatment of margin positive of residual lesions in uterine specimens after loop electrosurgical excision procedure in patients with cervical intraepithelial neoplasia

Abstract

Common treatment methods for patients with cervical intraepithelial neoplasia (CIN) include physical therapy and surgical treatment, and loop electrosurgical excisional procedure (LEEP) is relatively widely used in surgical treatment of CIN. However, some CIN patients were found margin positive of residual lesions in uterine specimens by biopsy after LEEP treatment, and the rate of margin positive of CIN was 4.51%-23.40%. A large number of studies have confirmed that margin positive of CIN is associated with postoperative residual lesions in uterine specimens by biopsy and recurrence of CIN. Further treatment strategies of patients with margins positive of CIN after LEEP treatment, no consensus has been reached in domestic and foreign studies of this area. At present, it is considered that the follow-up treatment of patients with CIN who have residual lesions and margins positive of CIN after receiving LEEP treatment need comprehensive evaluation and appropriate measures, especially for patients with positive of CIN in internal and external margins. This article focuses on latest research progresses of high-risk factors and treatment strategies in patients with margins positive of CIN after LEEP treatment, in order to provide reference for standardized clinical diagnosis and treatment of CIN patients. Key words: Cervical intraepithelial neoplasia; Uterine cervical neoplasms; Cervical resection; Hysterectomy; Loop electrosurgical excisional procedure; Margin positive of residual lesions; Biopsy; Female