Logistic regression analysis of pregnancy outcome and related factors in cervical loop electrosurgical excision procedure for cervical intraepithelial neoplasia

Abstract

Objective To investigate the pregnancy outcome of cervical intraepithelial neoplasia (CIN) by loop electrosurgical excision procedure (LEEP), and to analyze the related factors by logistic regression. Methods Seventy-six cases of cervical intraepithelial neoplasia treated in Shanxi Provincial People’s Hospital from February 2015 to January 2018 were selected as the observation group, and 76 healthy pregnant women in the same period were randomly selected as the control group. The delivery mode, pregnancy outcome and related factors of the two groups were observed and analyzed by Logistic regression analysis. Results The cesarean section rate of the observation group (72.4%) was higher than that of the control group (47.4%), the natural childbirth rate of the control group (42.1%) was higher than that of the observation group (18.4%) (P all 0.05). The rate of premature delivery in the control group (5.3%) was lower than that in the observation group (15.8%, P 0.05). The patients with residual cervical canal length > 1 cm and patients with resection volume less than 4 cm3 had better pregnancy outcomes, and the difference was significant (P<0.05). There was close relationship between the resection of tissue volume and the remaining cervical canal length. The longer the length of the uterine cervix was, the lower the risk of bad pregnancy outcome was; the greater the volume of the excised tissue was, the higher the risk of bad pregnancy outcome was. Conclusions The effect of cervix loop electrocution on the pregnancy outcome of cervical intraepithelial neoplasia is less, but it will increase the rate of caesarean section and premature delivery. The volume of tissue and the length of the remaining cervical canal are closely correlated with the outcome of the pregnancy, which can guide the safety of clinical use. Key words: Loop electrosurgical excision procedure; Cervical intraepithelial neoplasia; Pregnancy outcome