Effect of intratympanic injection of triamcinolone acetonid on IL-4 and IFN-γ in patients with secretory otitis media

Abstract

Objective To study the effect of intratympanic injection of triamcinolone acetonid on interleukin-4(IL-4) and interferon-gamma (IFN-γ) in patients with secretory otitis media. Methods 110 patients with secretory otitis media were selected, and they were randomly divided into the observation group and control group according to digital table, 55 cases in each group.All patients were treated with puncture in the tympanic cavity.The control group was injected with dexamethasone, while the observation group was injected with triamcinolone acetonid.Two groups were treated for 2 times/week, continuous treatment for 1 month.Fasting blood samples were collected before and after treatment to determine serum IL-4 and IFN-γ levels. Results The total effective rate of the control group was 58.2%, which was significantly lower than 70.9% of the observation group (χ2=4.68, P<0.05). After treatment, the serum levels of IL-4 and IL-4/IFN-γ in the two groups were significantly decreased (t=4.698, 10.262, 3.924, 4.264, all P<0.01). After treatment, the serum IFN-γ levels were significantly higher in the two groups(t=3.016, 5.116, all P<0.05). Compared with the control group after treatment, the serum IL-4, IL-4/IFN-γ in the observation group decreased more significantly (t=3.082, 2.971, all P<0.01). The serum IFN-γ level increased significantly (t=2.142, P<0.05). Conclusion Triamcinolone acetonid intratympanic injection can significantly improve the efficacy in patients with secretory otitis media, and improve the balance of Th1/Th2. Key words: Otitis media with effusion; Triamcinolone acetonid; Interleukin-4; Interferon-gamma