Clinical significance and influence of Yangyin Yiqi mixture on levels of interferon-γ and interleukine-10 in serum and saliva of oral lichen planus patients

Abstract

Objective To evaluate the clinical efficacy of Yangyin Yiqi mixture and western medicine in the treatment of oral lichen planus(OLP) and its effect on the levels of interferon-γ(IFN-γ) and interleukine-10(IL-10) in serum and saliva. Methods Sixty patients with OLP were randomly divided into control group(n=30) and treatment group(n=30). The control group was treated with triamcinolone acetonide and lidocaine, local injection.The treatment group was treated with Yangyin Yiqi mixture on the basis of the control group.The treatment lasted two months.After treatment, the clinical efficacy, objective indicators score, levels of IFN-γ and IL-10 in serum and saliva, adverse reactions were compared between the two groups. Results The overall response rate of the treatment group (86.67%) was significantly higher than that of the control group (63.33%)(χ2=11.64, P<0.01). After treatment, the two groups' objective index score significantly reduced(t=8.52, 12.51, all P<0.01), and the treatment group's objective indicators rating was significantly lower than the control group (t=4.38, P<0.05). After treatment, the levels of IFN-γ in serum and saliva were (25.39±1.29)pg/mL and (12.76±1.28)pg/mL, which were significantly increased in the treatment group (t=10.35, 8.15, all P<0.01), so did the control group (P<0.05). And the levels of IL-10 in serum and saliva were (27.54±1.82)pg/mL and (9.92±0.86)pg/mL, and the levels were significantly decreased in the two groups after treatment (t=8.76, 9.39, all P<0.01, t=4.65, 4.94, all P<0.05). And levels of IFN-γ in serum and saliva of the treatment group were significantly higher than those of the control group (t=4.68, 4.32, all P<0.05), and levels of IL-10 in serum and saliva of the treatment group were significantly lower than those of the control group (t=5.41, 5.25, all P<0.05). During treatment, there were no significant adverse reactions. Conclusion Yangyin Yiqi mixture combined with western medicine has definitive clinical efficacy in the treatment of OLP.It can significantly increase the level of IFN-γ and reduce the level of IL-10 in serum and saliva in patients, so provide theory value for treatment of OLP. Key words: Oral lichen planus; Yangyin Yiqi mixture; Interferon-γ; Interleukine-10