Effect of enalapril maleate and folic acid tablets in the treatment of H type hypertension and its influence on blood homocysteine

Abstract

Objective To study the clinical effect of enalapril maleate and folic acid tablets in the treatment of H type hypertension, and to observe the blood homocysteine(Hcy), to provide the basis for clinical diagnosis and treatment. Methods 126 patients with H type hypertension were selected. They were divided into study group and control group according to the random number table method, 63 cases in each group. The control group was given enalapril maleate, the study group was given enalapril maleate and folic acid tablets. The clinical efficacy of the two groups was compared. The systolic blood pressure, diastolic blood pressure and Hcy level before and after treatment in two groups were observed. Results The total effective rate of the study group was 90.5%(57/63), which of the control group was 74.6%(47/63), the difference was statistically significant(χ2=15.371, P 0.05). The systolic pressure after treatment of the two groups were (129.3±5.7)mmHg and (137.9±4.9)mmHg, the diastolic blood pressure were (81.5±3.6)mmHg and (89.6±5.1)mmHg, the differences were statistically significant compared with before treatment(t=8.969, 7.851, 7.343, 6.987, all P 0.05), after treatment Hcy levels of the two groups were (8.93±0.63)μmol/L and (15.35±0.57)μmol/L respectively, the differences were statistically significant compared with before treatment(t=8.097, 8.031, all P<0.05), the difference between the two groups was statistically significant(t=7.573, P<0.05). Conclusion Enalapril maleate and folic acid tablets in the treatment of H type hypertension has good clinical effect, can significantly lower blood pressure, improve Hcy level. Key words: Hypertension; Homocysteine; Enalapril maleate and folic acid tablets