Abstract
In this paper, the mechanical properties of extended drug release systems were studied. A binder is a material that is added to a formulation in order to improve the mechanical strength of a drug release system. The drug release systems investigated were cylindrical tablets containing mixtures of various ketoprofen types and binders. Among the binders used were a series of different molecular weights of kollidon va 64, carbopol 971 pnf, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. The samples were made in the form of cylindrical tablet of about 9 mm in diameter and containing different mixtures of drug substances and excipients in three formulations. Mechanical parameters such as hardness, tensile stress and friability were studied in order to determine how they are influenced by binder and how it influences wetting and disintegration of tables.
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