Abstract
The purpose of this research work is to formulate and evaluate diclofenac sodium buccal tablets using semi-synthetic polymers such as hydroxypropyl methyl cellulose K4M (HPMC K4M), methyl cellulose (MC) and sodium carboxyl methyl cellulose (SCMC) along with ethyl cellulose (EC) as the backing membrane. The drug excipient compatibility study was carried out by Fourier transform infrared spectroscopy. The diclofenac sodium buccal tablets were formulated by direct compression method. The prepared diclofenac sodium buccal tablet were evaluated for general appearance, hardness, weight variation, thickness, swelling studies, drug content, friability test, in vitro disintegration test, in vitro dissolution test, in vitro drug release kinetic and ex vivo residence time.
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