Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen

Monica Iliuta Stamate,Bogdan Ciuntu,Alina Stefanache,Lacramioara Ochiuz,Carmen Gafitanu,Daniel Timofte,Ciprian Stamate

doi:10.37358/mp.19.1.5159

Abstract

In this study, the effect of polymers on the mechanical properties of ketoprofen extended drug release systems were studied. Many polymers are added in formulation of compressed tablets in order to improve the physicochemical characteristics of the drug release system. The samples were made in the form of cylindrical tablet about 9 mm in diameter, containing different mixtures of drug substances and excipients acording to seven formulations. Cylindrical tablets containing mixtures of ketoprofen and various types of polymers are made by direct compression method. Among the binders used were a series of different polymers like Kollidon va 64, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. Mechanical parameters such as hardness, mechanical strenght, friability and roughness were studied in order to determine how they are influenced by polymeric binders.

Highlights

In this study, the effect of polymers on the mechanical properties of ketoprofen extended drug release systems were studied
The formulas (F1-F7) used for each set of tablets have the same concentrations of ketoprofen like active ingredient and different concentrations of polymeric excipients, according to the table 1
The binders like Kollidon and hydroxypropyl methylcellulose (HPMC) K100M powders were mixed in various ration to obtain powders with different plastoelasticity

Summary

Introduction

The effect of polymers on the mechanical properties of ketoprofen extended drug release systems were studied. Among the binders used were a series of different polymers like Kollidon va 64, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose Mechanical parameters such as hardness, mechanical strenght, friability and roughness were studied in order to determine how they are influenced by polymeric binders. There is a question of optimizing the formulation in quantitative terms, that is, the quantity of an excipient and the parameters of the technological process [1] At this stage, the substances (for pharmaceutical use) to be studied are determined, in which case the active substance with therapeutic effect is ketoprofen and the excipients are specific for direct compression. Ketoprofen is an active principle belonging to the analgesic-antipyretic-anti-inflammatory group, where the anti-inflammatory effect prevails This drug removes or diminishes some symptoms and signs of inflammation in rheumatic diseases [2]. Contraindications refer to known allergies to ketoprofen or other non-steroidal inflammatory drugs, evolved gastroduodenal ulcer, severe hepatic impairment, severe renal impairment and pregnancy

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