Abstract
Objective To observe the effect of different dosage of mecobalamin in treating patients with chronic alcoholic peripheral neuropathy.Methods 85 patients with chronic alcoholic peripheral neuropathy were randomly divided into group A(n =29),group B(n =28)and group C(n =28).Patients of all 3 groups were treated with conventional therapy.In addition,mecobalamin 1500 μg intravenously guttae once a day,mecobalamin 500 μg intravenously guttae once a day were given to patients in group A and B,respectively.Patients in group C were not given mecobalamin.After 4 weeks,improving and nerve conductive velocity were assessed for comparison.Results After 4 weeks' therapy,patients of all 3 groups were remarkably improved.Therapeutic effects of group A and B were better than group C ( all P ＜ 0.01 ),and group A was better than group B ( P ＜ 0.05).Nerve conductive velocity of patients in all 3 groups were raised markedly( P ＜0.05).Patients with mecobalamin therapy( patients in group A&B) showed significantly greater improvement in nerve conductive velocity( P ＜ 0.05 ) and high dose group( group A ) was better than group B(P ＜0.05).Conclusion Mecobalamin has a curative effect on chronic alcoholic peripheral neuropathy and high dose therapy is better than regular dose. Key words: Mecobalamin; Peripheral neuropathy, toxic, alcoholic ; Nerve conductive velocity
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