Effect of different antibiotic therapy in the treatment of patients with chronic pelvic inflammation disease and the influence on inflammatory factors

Abstract

Objective To compare the effects of different antibiotic regimens on clinical efficacy and inflammatory factors in patients with chronic pelvic inflammatory disease. Methods 78 patients with chronic pelvic inflammatory disease were enrolled.They were randomly divided into observation group(antibiotic sequential method) and control group(sequential transformation of antibiotics) by computer generation test case random number method, 39 cases in each group.After treatment for 10 days, the clinical efficacy was observed, the serum IL-1 and IL-2 levels before and after treatment were compared.The economic costs, adverse events during the course of treatment were compared between the two groups, and 6 months after treatment, the recurrence was followed up in the two groups. Results After 10 days of treatment, the total effective rate was 94.59% in the observation group and 86.49% in the control group.The total remission rate in the observation group was higher than that in the control group(χ2=5.41, P=0.002). Before treatment, the levels of IL-1 and IL-2 of the observation group were (413.47±38.59)μg/L, (489.43±44.58)ng/L, respectively, which of the control group were (419.47±40.46)μg/L, (490.47±47.40)ng/L, respectively, and the differences were not statistically significant between the two groups (t=0.65, 0.10, P=0.52, 0.92). After treatment, the IL-1 level of the observation group[(288.53±32.48)μg/L] was lower than before treatment (t=15.07, P=0.00), and IL-2 level [(288.53±32.48)ng/L] was higher than before treatment (t=14.65, P=0.00). After treatment, the IL-1 level of the control group[(358.41±43.47)μg/L] was lower than before treatment (t=15.07, P=0.00), and IL-2 level [(550.46±32.90)ng/L] was higher than before treatment (t=14.65, P=0.00). The improvement of IL-1 and IL-2 levels in the observation group were better than those in the control group (t=7.83, 9.66, all P=0.00). The cost of drug and drug expense of the observation group were (115.47±3.48)RMB and (27.45±2.01)RMB, respectively, which of the control group were (120.45±3.39)RMB, (27.45±2.01)RMB, respectively, the differences between the two groups were not statistically significant (t=2.44, 0.00, P=0.17, 1.00). There were 2 cases with gastrointestinal discomfort in the observation group and 1 case in the control group, the difference between the two groups was not statistically significant (χ2=0.35, P=0.56). The adverse reactions of two groups were relatively minor, self-mitigation or disappeared after withdrawl the drug.After treatment for 6 months, the recurrence rate was 2.56%(1/39) in the observation group and 15.38%(6/39) in the control group.The recurrence rate of the observation group was lower than that of the control group(χ2=3.92, P=0.04). Conclusion The antibiotic sequential conversion therapy is the first intravenous antibiotics, and then oral combination, the recent and long-term clinical efficacy is good, and it is safe and reliable, without increasing the economic burden of patients, and is worthy of clinical use. Key words: Pelvic inflammatory disease; Anti-infective agents; Interleukins