Abstract
Osteoporosis and diabetes mellitus (DM) are widespread diseases and have a significant health burden. Type-1 diabetes mellitus (T1DM) and Type-2 diabetes mellitus (T2DM) are associated with an increased bone fracture. In T1DM, the increased risk of bone fracture is associated with low bone mass. In patients with T2DM, the risk of fracture of the bone is increased due to low quality of bone, despite increased bone mineral density (BMD). In type 2 diabetic patients, bone fragility depends on the quality of bone instead of a reduction in bone mass. Thiazolidinediones (TZD) cause differentiation of adipocytes and inhibit differentiation of osteoblast and bone marrow stromal stem cells (BMSC). In this review, we have described the effect of anti-diabetic drugs and diabetes mellitus on bone health and our finding shows that sulfonylureas and metformin have no negative effect on bone health and protect bones against fractures.
Highlights
Damage bone quality and expanded bone fracture chance have emerged as a diagnosed complication of diabetes mellitus (Zamarioli et al, 2020)
These impacts are intervened by AGEs products, which are generated because of non-enzymatically glycosylation of lipids or protein and are concerned in the various complication of diabetes, bone fragility is included (Goldin et al, 2006). Proof for this was furnished by an investigation in rodents with diabetes mellitus 1 (DM1) which indicated an expansion in the non-enzymatic cross-connecting in diabetic rodents contrasted with controls (Silva et al, 2009). Supplementing these outcomes are those from a medical cross-sectional investigation that exhibited that a higher level of serum of pentosidine was related to cracks in patients with diabetes mellitus type1 in the wake of modifying for age, smoking, body mass index, the inadequacy of vitamin D, family ancestry of cracks and bone mass density at the femoral neck, lumbar spine and all-out hip (Neumann et al, 2014)
Osteoporosis and bone fractures are prevalent in DM
Summary
See page for additional authors Follow this and additional works at: https://corescholar.libraries.wright.edu/jbm. Authors Farah Deeba, Sidra Younis, Nida Qureshi, Tahmina Mustafa, Nadia Iqbal, and Saira Hussain © Copyrights of all the papers published in Journal of Bioresource Management are with its publisher, Center for Bioresource Research (CBR) Islamabad, Pakistan. This permits anyone to copy, redistribute, remix, transmit and adapt the work for non-commercial purposes provided the original work and source is appropriately cited. This article is available in Journal of Bioresource Management: https://corescholar.libraries.wright.edu/jbm/vol8/ iss2/13. FARAH DEEBA1*, SIDRA YOUNIS2, NIDA QURESHI1, TAHMINA MUSTAFA1, NADIA IQBAL1, SAIRA HUSSAIN3
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