Effect of Banxie Xiexin decoction in the treatment of duodenum ulcer complicating HP infection

Abstract

Objective To observe the effect of Banxie Xiexin decoction in the treatment of duodenum ulcer complicating HP infection and its influence on IL-6. Methods Retrospective analysis of 80 patients with duodenum ulcer complicating HP infection were conducted.The patients were tested by rapid urease test for Hp infection.All the patients were randomly divided into observation group (40 cases) and control group(40 cases) according to random number table generated by SPSS19.0.The control group was treated with triple therapy(omeprazole, clarithromycin, amoxicillin). The observation group was given Banxie Xiexin decoction on the basis of the control group, 14d as a course.Before and after treatment, the Hp eradication rate was calculated.The epigastric burning, belching tunsuan, dry mouth and limbs without temperature score were measured.5mL fasting blood was exsanguinated to test IL-6.The clinical efficacy was compared. Results The eradication rate of Hp in the observation group was 85%, which was significantly higher than that in the control group(55%). The difference was statistically significant(χ2=8.571, P<0.05). The total effective rate of the observation group was 95%, which was significantly higher than that of the control group(75%). The difference was statistically significant(Z=-3.143, P<0.05). The epigastric burning, belching tunsuan, dry mouth and limbs without temperature score of the observation group and the control group after treatment were lower than before treatment(t=7.167 and 5.664, 6.919 and 5.713, 7.462 and 5.051, 7.372 and 5.136, all P<0.05), which of the observation group after treatment were lower than those of the control group(t=4.501, 4.464, 4.388, 4.506, all P<0.01). The IL-6 levels of the observation group and the control group after treatment were (184.3±92.2)pg/mL and (283.6±102.8)pg/mL respectively, which were significantly lower than before treatment(t=14.332, 6.325, all P<0.05). The IL-6 level of the observation group after treatment was significantly lower than the control group(t=7.254, P<0.05). Conclusion Banxia Xiexin decoction can improve the clinical curative effect of triple therapy in the treatment of duodenum ulcer complicating HP infection, improve the clinical symptoms, improve the eradication rate of Hp and restrain the local inflammatory factors, so as to relieve mucosal injury. Key words: Duodenal ulcer; Helicobacter, pylori; Interleukin-6; Banxia xiexin decoction