Effect of atorvastatin in the treatment of coronary heart disease patients with different Gensini score and its influence on hs-CRP level

Abstract

Objective To study the effect of atorvastatin on the levels of high sensitive C-reactive protein(hs-CRP) in coronary heart disease(CHD) patients with different Gensini score. Methods 120 cases of CHD from March 2011 to September 2015 in our hospital were selected as the research subjects.According to the different Gensini scores, they were divided into group A(Gensini score 80), with 30 patients in each group.All patients were given atorvastatin treatment, the therapeutic effect of the four groups, the total cholesterol(TC), three glycerol(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) and hs-CRP levels after treatment were compared. Results After treatment, the lower the Gensini score, the better curative effect, four groups had statistically significant difference in the therapeutic effects(P<0.05), and the total effective rates of group A, B, C and D were 96.7%, 86.7%, 76.6%, 56.7%.After treatment, the TG, TC, HDL-C, LDL-C in four groups were improved, A group improved significantly better than the B group, B group improved better than those of C group, C group improved better than those of D group, the differences were statistically significant(F=6.253, 6.258, 5.856, 6.259, all P<0.05). After treatment, the levels of hs-CRP in group A, B, C and D were (8.2±3.9)mg/L, (11.9±6.9)mg/L, (19.2±9.3)mg/L, (24.5±11.6)mg/L, the hs-CRP levels of four groups were lower, hs-CRP level after treatment in group A was lower than that of B, C, D groups; and hs-CRP level after treatment in group B was lower than that of group C, D; hs-CRP level of C group after treatment was lower than that of group D. The differences were statistically significant(t=12.651, 9.185, 4.982, 3.030, all P<0.05). Conclusion The level of serum hs-CRP in patients with CHD is higher, and the level of hs-CRP is positively correlated with the Gensini score. Key words: Coronary disease; Atorvastatin; Gensini score; C-reactive protein