The analysis of the changes of high density lipoprotein cholesterol and high sensitivity C reactive protein in coronary heart disease patients combined with type 2 diabetes mellitus

Abstract

Objective To explore the significance of the changes of high density lipoprotein cholesterol (HDL-C) and high sensitivity C reactive protein (hs-CRP) in coronary heart disease patients combined with type 2 diabetes mellitus, and analyze the relationship between HDL-C and hs-CRP. Methods Two hundred and ten elder patients were selected. The patients were divided into simple coronary heart disease group (A group, 70 cases) , coronary heart disease combined with type 2 diabetes mellitus group (B group, 71 cases) , and simple type 2 diabetes mellitus group (C group, 69 cases) according to the pathogenetic condition. Meanwhile 50 healthy controls were selected as control group (D group) . The levels of HDL-C and hs-CRP were measured, and correlation analysis used Pearson linear correlation. Results The levels of HDL-C in A, B and C group were significantly lower than those in D group: (1.98±0.47) , (0.99±0.31) and (1.27±0.44) mmol/L vs. (2.18±0.42) mmol/L, and there were statistical differences (P 0.05) ; hs-CRP and fasting plasma glucose (FPG) had signficant positive correlation (r=0.415,P<0.01) , and hs-CRP and glycosylated hemoglobin (HbA1c) had signficant positive correlation (r=0.384,P<0.01). Conclusions The levels of HDL-C in patients with elder patients with simple coronary heart disease and simple type 2 diabetes mellitus are significantly lower, and the levels of hs-CRP are significantly higher. The level of HDL-C in elder coronary heart disease patients combined with type 2 diabetes mellitus is significantly lower than that in elder patients with simple coronary heart disease and simple type 2 diabetes mellitus, and the level of hs-CRP is significantly higher than that in elder patients with simple coronary heart disease and simple type 2 diabetes mellitus. The level of hs-CRP is HDL-C have signficant negative correlation. Key words: Coronary disease; Diabetes mellitus, type 2; Cholesterol, HDL; C reactive protein; Aged