Correlationship between high sensitive C -reactive protein and interleukin -6 in patients with type 2 diabetes mellitus complicated with coronary artery disease

Abstract

Objective To investigate the correlationship between high sensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in patients with diabetes mellitus complicated with coronary artery disease. Methods Eighty patients with T2DM were divided into two groups:40 cases complicated with coronary artery disease,40 cases without coronary artery disease, and 40 healthy people as control group. The levels of serum hs-CRP, blood lipid and IL-6 were compared between patients of three groups.Results Levels of hs-CRP and IL-6 were significantly higher in patients with T2DM than those in control group(P<0.01);and were significantly higher in patients with coronary artery disease than those without coronary artery disease(P<0.01).Conclusions Levels of hs-CRP and IL-6 were significantly higher in patients with T2DM complicated with coronary artery disease, and the close correlationship between hs-CRP and IL-6 may contribute to the pathogenesis of this process. Key words: Type 2 diabetes mellitus ; High sensitive C-reactive protein ; Interleukin-6 ; Coronary heart disease ;