Abstract
The purpose of this study was to determine the number of luminal neutrophils at the time of implantation when an IUD was inserted following mating. Mature Holtzman rats were mated and on days 1, 2, 3 or 4 of pregnancy, a silk thread or polyethylene IUD, 17–22 mm long, was inserted into the cervical half of a uterine horn. The other uterine horn was sham-treated. The rats were autopsied on day 5 of pregnancy and the treated portions of the uterine horns were each flushed with 0.2 ml Hank's solution. The numbers of uterine luminal neutrophils were counted on a hemocytometer chamber. The neutrophilic response occurred in all horns as early as 24 hr after treatment. More neutrophils were observed in rats with a silk IUD than in those with a polyethylene IUD and there were more neutrophils in the IUD horns than in the sham-treated ones. These data are compatible with the possibility that neutrophils have a role in preventing implantation in the rat.
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