Abstract
The present study was designed to determine how effective a polyethylene device (10–15 mm long) was in preventing implantation of rat blastocysts when it was placed in different locations of the uterine horn. Adult Holtzman rats had the device placed in the cervical half or ovarian half of one uterine horn three weeks prior to mating and were killed on days 7–9 of pregnancy. Although implantation did not occur in that portion of a rat uterine horn in contact with the polyethylene IUD, implantation could occur above or below the device. More animals had implantation sites when the IUD was located at the cervical half than at the ovarian portion of the horn. It is not clear why this occurs; one possibility is considered. A comparison of the composition of several devices as to their effectiveness in suppressing implantation is also considered.
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