Dynamic change of plasma D-dimer level in patients with acute craniocerebral injury and cerebral hemorrhage and its significance

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Objective To explore the dynamic change and clinical significance of plasma D-dimer level in patients with cerebral hemorrhage and acute craniocerebral injury. Methods 50 patients with cerebral hemorrhage and 40 patients with acute craniocerebral injury were selected, The enzyme-linked immunosorbent assay (ELISA) was used to measure plasma D-dimer level in two groups of patients after onset, and the results were compared with 40 healthy controls. Results The levels of plasma D-dimer in the patients with cerebral hemorrhage were 1.59mg/L, 2.10mg/L, 1.03mg/L, 0.82mg/L at 3h, 6h, 12h, 2d after onset, which in the patients with acute craniocerebral injury were 1.61mg/L, 2.02mg/L, 1.01mg/L and 0.67mg/L, respectively.And the plasma D-dimer levels were 0.50mg/L, 0.49mg/L, 0.47mg/L, 0.48mg/L in the control group at 3h, 6h, 12h and 2d after onset.The levels of plasma D-dimer in the patients with acute craniocerebral injury were significantly higher than those in the control group, and the differences were statistically significant (t=9.35, 12.17, 4.03, 3.05, all P 0.05). Conclusion Cerebral hemorrhage patients and acute craniocerebral injury patients have high coagulation and fibrinolytic activity in brief increase trend, dynamic observation of plasma D-dimer level in patients with cerebral hemorrhage and acute craniocerebral injury is helpful to determine courses, condition and evaluate prognosis. Key words: Craniocerebral trauma; Cerebral hemorrhage; D-dimer