The effect of blood glucose levels on the prognosis of acute severe traumatic brain injury patients

Abstract

Objective To explore the relationship between different blood glucose levels and prognosis in patients with acute severe craniocerebral injury. Methods Clinical data of 120 patients with acute severe craniocerebral injury from Jun. 2014 to Jun. 2017 in Department of Neurosurgery, Tongren Hospital of Wuhan University were analyzed retrospectively. The patients were divided into the group of acute severe craniocerebral injury and the group of acute extra-severe craniocerebral injury according to the Glasgow coma score (GCS) . Blood glucose levels were detected at the time of admission, the 1st day, the 3rd day, the 7th day and the 14th day after operation. According to the blood glucose levels on admission, the patients were divided into the normal blood glucose group, the blood glucose value of 6.1-10.0 mmol/L group, the blood glucose value > 10.0 mmol/L group. The prognosis was evaluated by Glasgow Outcome Score (GOS) 3 months after discharge. The relationship between the blood glucose levels and GOS score in different groups was analyzed. Results The blood glucose levels in the group of acute extra-severe craniocerebral injury were higher than those in the group of acute severe craniocerebral injury, and the difference was statistically significant (P 10.0 mmol/L, 31 had good prognosis and 24 had poor prognosis, with a good prognosis rate of 56.4% (31/55) . With the increase of blood glucose, the good prognosis rate gradually decreased and the poor prognosis rate gradually increased, and the difference was statistically significant (P=0.010, χ2=9.283) . Conclusion Blood glucose level has influence on the prognosis of patients with acute severe craniocerebral injury, and the good prognosis of patients with acute severe craniocerebral injury is severely affected by hyperglycemia. Key words: Blood glucose level; Acute severe craniocerebral injury; Hyperglycemia; Prognosis