Abstract
Serratia marcescens strains are ubiquitous bacteria isolated from environmental niches and also constitute emergent nosocomial opportunistic pathogens. Here, we report on the draft genome sequence of S. marcescens strain RM66262, which was isolated from a patient with urinary tract infection in the Bacteriology Service of the Rosario National University, Rosario, Argentina.
Highlights
Serratia marcescens strains are ubiquitous bacteria isolated from environmental niches and constitute emergent nosocomial opportunistic pathogens
In previous reports from our group, we demonstrated that this strain of S. marcescens, using an in vitro infection model of nonphagocytic cells, provokes an extracellular induction of autophagy mediated by ShlA pore-forming toxin, and is able to internalize, survive, and replicate inside large membrane-bound compartments that recruit prototypical markers of autophagosomes [6,7,8]
Earlier work from our group pointed to the S. marcescens Rcs system as a key player in the regulation of the expression of virulence determinants of the bacterium [5, 9]
Summary
Serratia marcescens strains are ubiquitous bacteria isolated from environmental niches and constitute emergent nosocomial opportunistic pathogens. Serratia marcescens is an opportunistic human pathogen associated with urinary and respiratory tract as well as wound and eye infections, endocarditis, osteomyelitis, meningitis, and septicemia. The incidence of S. marcescens infection has increased over the last years, mainly due to the acquisition of multiple antibiotic resistances [1,2,3,4]. The factors and mechanisms that contribute to Serratia pathogenesis remain unclear.
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