Abstract

Capnocytophaga canimorsus is a bacterium from the normal oral flora of dogs and cats that causes rare generalized infections in humans. In an attempt to determine whether infections could be caused by a subset of strains and to identify pathogenicity factors, we sequenced the genomes of three strains isolated from human infections.

Highlights

  • Capnocytophaga canimorsus is a bacterium from the normal oral flora of dogs and cats that causes rare generalized infections in humans

  • Capnocytophaga canimorsus is a Gram-negative commensal bacterium from the normal canine oral flora that causes lifethreatening septicemia in patients who have been in contact with dogs or cats [1]

  • The final hybrid assembly was performed with MIRA [14] and included pseudoreads corresponding to contigs mapped onto the reference chromosome of C. canimorsus strain 5 (Cc5) [5] using MAQ [15] and to contigs from the de novo assembly generated with Velvet with optimized parameters [16]

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Summary

Introduction

Capnocytophaga canimorsus is a bacterium from the normal oral flora of dogs and cats that causes rare generalized infections in humans. Infections present with fulminant sepsis [2, 3], including cases of meningitis, endocarditis, or myocarditis. Fastidious growth of the pathogen and lack of symptoms during the initial stages of infection often lead to an unattended wound [4], resulting in a mortality rate of as high as 30% [1].

Results
Conclusion
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