Abstract
The rise in antibiotic-resistant bacteria has spurred efforts to identify novel compounds with antimicrobial activity. This brief report describes the genome sequence of three Bacillus species isolates from South African marine sponges, which produce compounds with antimicrobial activity. A search for secondary metabolite clusters revealed several secondary metabolite pathways in these genomes, which may hold promise as novel antibiotics.
Highlights
The rise in antibiotic-resistant bacteria has spurred efforts to identify novel compounds with antimicrobial activity
We present the draft genome sequences of three Bacillus spp. (PE5-112, PE8-15, and PE8-121b), which were isolated from marine sponges
The genome sizes are ϳ5.91 Mbp (35.1% GϩC content), ϳ5.65 Mbp (35.2% GϩC content), and ϳ5.36 Mbp (37.9% GϩC content) for PE8-15, PE8121b, and PE5-112, respectively, with average coverages of 118, 28, and 311-fold
Summary
The rise in antibiotic-resistant bacteria has spurred efforts to identify novel compounds with antimicrobial activity. We present the draft genome sequences of three Bacillus spp. (PE5-112, PE8-15, and PE8-121b), which were isolated from marine sponges. Strain 001RSASPN and Waltherarndtia caliculatum, were collected in Algoa Bay off the coast of Port Elizabeth in the Eastern Cape region of South Africa.
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