Abstract
The probiotic Symbioflor 1 is a historical concoction of 10 isolates of Enterococcus faecalis. Pulsed-field gel electrophoresis revealed two groups: one comprising eight identical clones (DSM16430, DSM16432, DSM16433, DSM16435 to DSM16439) and a further two isolates (DSM16431, DSM16434) with marginally different profiles. Here, we report a comparative analysis of the draft genome sequences of representative isolates.
Highlights
The homeostasis of gut microbiota is essential for the maintenance of health, and infectious or metabolic imbalance can lead to gastrointestinal disorders [1,2,3]
The conceptual use of beneficial probiotic bacteria in regulating intestinal dysbiosis has been propagated, and the use of these microorganisms has been implicated in promoting health following consumption [4, 5]
The commercially available probiotic Symbioflor 1 (SymbioPharm, Herborn, Germany) comprises 10 probiotic Enterococcus faecalis isolates obtained from a healthy volunteer in the early 1950s
Summary
The homeostasis of gut microbiota is essential for the maintenance of health, and infectious or metabolic imbalance can lead to gastrointestinal disorders [1,2,3]. Modulation of the gut microbiota to prevent disease is an area of great interest. The conceptual use of beneficial probiotic bacteria in regulating intestinal dysbiosis has been propagated, and the use of these microorganisms has been implicated in promoting health following consumption [4, 5]. The commercially available probiotic Symbioflor 1 (SymbioPharm, Herborn, Germany) comprises 10 probiotic Enterococcus faecalis isolates obtained from a healthy volunteer in the early 1950s.
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