Abstract
The altered Schaedler flora (ASF) is a bacterial community that supports normal growth and development of gnotobiotic mice. We report here the draft genome sequences of the 8 bacteria that comprise the ASF.
Highlights
The altered Schaedler flora (ASF) is a bacterial community that supports normal growth and development of gnotobiotic mice
A significant challenge to these studies moving forward is the high abundance and diversity of bacterial species that colonize the mammalian GI tract, which is dominated by members of the phyla Bacteroidetes and Firmicutes [3]
The ASF mouse model is derived from the work of Schaedler et al, who colonized germfree mice with a consortium of bacteria that originated from conventional mice [11]
Summary
The altered Schaedler flora (ASF) is a bacterial community that supports normal growth and development of gnotobiotic mice. Recent studies have added to our understanding by providing new mechanistic insights into host-microbiota interactions [1, 2]. A significant challenge to these studies moving forward is the high abundance and diversity of bacterial species that colonize the mammalian GI tract, which is dominated by members of the phyla Bacteroidetes and Firmicutes [3].
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