Abstract
Bordetella hinzii is a Gram-negative bacterium known to infect poultry, humans, rabbits, and rodents. It is an opportunistic pathogen in immunocompromised humans, and some strains cause mild to moderate respiratory disease in turkeys. Little is known as to the degree of genetic diversity within the species or the genetic basis for virulence. Here, we report the genome sequences of six isolates of B. hinzii acquired from humans, rabbits, or turkeys. These data provide a framework for refining the population structure of the genus, establishing relationships among genetically distinct isolates, and developing an understanding of the possible virulence mechanisms of the bacterium.
Highlights
Bordetella hinzii is a Gram-negative bacterium known to infect poultry, humans, rabbits, and rodents
Bordetella hinzii, which has been recognized as a distinct species only since 1995 [1], is most frequently isolated from poultry
Of the virulence factors conserved among the classical Bordetella (B. pertussis, B. parapertussis, and B. bronchiseptica), filamentous hemagglutinin, pertactin, and dermonecrotic toxins appear to be absent in B. hinzii; most remaining Bordetella virulence factors have yet to be fully evaluated
Summary
Bordetella hinzii is a Gram-negative bacterium known to infect poultry, humans, rabbits, and rodents. Bordetella hinzii, which has been recognized as a distinct species only since 1995 [1], is most frequently isolated from poultry. The bacterium was initially regarded as nonpathogenic in avian hosts, some strains induce mild to moderate respiratory disease in turkeys [2]. B. hinzii is an opportunistic human pathogen and has been associated with respiratory disease, septicemia, and cholangitis in immunocompromised individuals [3,4,5,6,7,8,9,10].
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