Abstract
Bovine tuberculosis (BTB), a zoonotic infection of cattle caused by Mycobacterium bovis, results in losses of $3 billion to the global agricultural industry and represents the fourth most important livestock disease worldwide. M. bovis as a source of human infection is likely underreported due to the culture medium conditions used to isolate the organism from sputum or other sample sources. We report here the draft genome sequences of M. bovis BZ 31150, isolated from a bronchial washing from a captive chimpanzee, and M. bovis B2 7505, isolated from a human sputum sample in Uganda.
Highlights
Zoonotic transmission of bovine tuberculosis is a major concern in pastoral settings of the developing world, where animal-human interface is close and HIV prevalence is high
The continued transmission of Mycobacterium bovis, which is resistant to pyrazinamide, leads to treatment failures necessitating improved diagnostics to inform national and international tuberculosis (TB) surveillance efforts
Human cases of bovine tuberculosis are underreported in these areas, primarily because glycerol, which is used as a carbon source to grow Mycobacterium tuberculosis, is not optimal for M. bovis growth
Summary
Zoonotic transmission of bovine tuberculosis is a major concern in pastoral settings of the developing world, where animal-human interface is close and HIV prevalence is high. The continued transmission of Mycobacterium bovis, which is resistant to pyrazinamide, leads to treatment failures necessitating improved diagnostics to inform national and international tuberculosis (TB) surveillance efforts. The extent of human tuberculosis caused by M. bovis is largely unknown due to a lack of accurate laboratory testing, especially in resource-limited settings of the world.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
