Abstract
Nonencapsulated Streptococcus pneumoniae can colonize the human nasopharynx and cause conjunctivitis and otitis media. Different deletions in the capsular polysaccharide biosynthesis locus and different multilocus sequence types have been described for nonencapsulated strains. Draft genome sequences were generated to provide insight into the genomic diversity of these strains.
Highlights
Nonencapsulated Streptococcus pneumoniae can colonize the human nasopharynx and cause conjunctivitis and otitis media
Colonization of the human nasopharynx by Streptococcus pneumoniae is a prerequisite for pneumococcal pneumonia, meningitis, and otitis media [1, 2]
More than 50% of children under five years old in the United States have been colonized by S. pneumoniae [3, 4]
Summary
Nonencapsulated Streptococcus pneumoniae can colonize the human nasopharynx and cause conjunctivitis and otitis media. The incidence of invasive pneumococcal disease (IPD) has significantly decreased since the introduction of conjugate vaccines based on seven, and more recently, 13 capsular polysaccharides [5, 6]. The incidences of carriage and IPD have increased for some capsular serotypes not covered by the conjugate vaccines [7, 8], and the incidence of carriage has increased for nonencapsulated and nontypeable pneumococci [9, 10].
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