Abstract
Saccharopolyspora rectivirgula is the main cause of farmer’s lung disease. The development of recombinant antigens to standardize the serodiagnosis of the disease requires knowledge of the S. rectivirgula genome. We sequenced the genome of an environmental strain, S. rectivirgula DSM 43113. A total of 3,221 proteins were found to be encoded in a short 3.9-Mb genome.
Highlights
Saccharopolyspora rectivirgula is the main cause of farmer’s lung disease
The farmer’s lung disease (FLD) diagnosis is complex because it requires an association of clinical and biological markers, including serum-precipitating antibodies against offending antigens [2, 3]
The working group of lung disease experts has stressed the need for standardized antigens for FLD diagnosis [5]
Summary
Saccharopolyspora rectivirgula is the main cause of farmer’s lung disease. The development of recombinant antigens to standardize the serodiagnosis of the disease requires knowledge of the S. rectivirgula genome. The thermophilic actinomycete Saccharopolyspora rectivirgula (syn., Micropolyspora faeni, Faenia rectivirgula) is the main etiological agent of farmer’s lung disease (FLD), a common type of occupational hypersensitivity pneumonitis [1]. The FLD diagnosis is complex because it requires an association of clinical and biological markers, including serum-precipitating antibodies against offending antigens [2, 3]. The serological tests that are routinely performed rely on unstandardized crude antigens [4]. The working group of lung disease experts has stressed the need for standardized antigens for FLD diagnosis [5].
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