Abstract
The draft genome sequence of the oleaginous yeast Yarrowia lipolytica stain PO1f, a commonly used metabolic engineering host, is presented here. The approximately 20.3-Mb genome sequence of PO1f will greatly facilitate research efforts in metabolic engineering of Yarrowia lipolytica for value-added chemical production.
Highlights
The draft genome sequence of the oleaginous yeast Yarrowia lipolytica stain PO1f, a commonly used metabolic engineering host, is presented here
To gain a better understanding of the strain W29 and its potential for value-added chemical production, we generated the genome sequence for its derivative strain, PO1f
The reads were assembled using Velvet with a k-mer size of 55 [21]. This led to a genome assembly containing 669 contigs
Summary
The draft genome sequence of the oleaginous yeast Yarrowia lipolytica stain PO1f, a commonly used metabolic engineering host, is presented here. A nonconventional oleaginous yeast, has recently emerged as a potential host strain that is recognized both as safe [1] and as a potent producer of value-added chemicals and industrial protein [2, 3]. Recent efforts have further expanded the genetic toolbox for Y. lipolytica [4, 5] and rewired metabolic networks for high-level production of fatty acid-based value-added chemicals [6,7,8,9]. A high-quality genome sequence of Y. lipolytica strain CLIB122 (E150) has been available [10], this strain is not the most popular for metabolic engineering applications.
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