Draft Genome Sequence of the Intermediate Rough Vaccine Strain Brucella abortus S19Δ per Mutant

Pallab Chaudhuri,Udayakumar S Vishnu,Jeyaprakash Rajendhran,Gurpreet Kaur,Paramasamy Gunasekaran,Tapas K Goswami T,Jonathan Lalsiamthara,Jagadesan Sankarasubramanian

doi:10.1128/genomea.01336-15

Pallab Chaudhuri, Udayakumar S Vishnu + Show 6 more

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https://doi.org/10.1128/genomea.01336-15

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Abstract

Here, we report the genome sequence of the intermediate rough vaccine strain mutant, Brucella abortus S19Δper. The length of the draft genome was 3,271,238 bp, with 57.2% G+C content. A total of 3,204 protein-coding genes and 56 RNA genes were predicted.

Highlights

We report the genome sequence of the intermediate rough vaccine strain mutant, Brucella abortus S19⌬per
Brucella abortus strain S19 is widely used as the vaccine strain for the control of bovine brucellosis in different countries (1)
The B. abortus S19⌬per mutant is more ideal than B. abortus S19 in terms of safety, potency, and differentiation of infected and vaccinated animals and is capable of serving as an alternate vaccine candidate for the control of bovine brucellosis (4)

Summary

Introduction

We report the genome sequence of the intermediate rough vaccine strain mutant, Brucella abortus S19⌬per. Brucellosis is a zoonotic disease caused by Brucella. It infects a wide range of hosts. Brucella abortus strain S19 is widely used as the vaccine strain for the control of bovine brucellosis in different countries (1). Perosamine synthetase, coded by the per gene, polymerizes the monomeric units of O-polysaccharide (OPS) (2).

Results

Conclusion