Abstract
We report the draft genome sequence of Streptomyces sp. TP-A0874 isolated from compost. This strain produces catechoserine, a new catecholate-type inhibitor of tumor cell invasion. The genome harbors at least six gene clusters for polyketide and nonribosomal peptide biosyntheses. The biosynthetic gene cluster for catechoserines was identified by bioinformatic analysis.
Highlights
We report the draft genome sequence of Streptomyces sp
TP-A0874, was isolated from a compost sample collected in Ishikawa, Japan, and found to produce a new catecholate derivative designated catechoserine, along with two known biosynthetically related metabolites, N,N=-bis(2,3-dihydroxybenzoyl)-O-L-seryl-L-serine and N,N=,N=-tris(2,3-dihydroxybenzoyl)-O-L-seryl-O-L-seryl-L-serine
To identify the biosynthetic gene cluster for these compounds and assess the potential to produce other secondary metabolites, we sequenced the genome of Streptomyces sp
Summary
We report the draft genome sequence of Streptomyces sp. TP-A0874 isolated from compost. In our search for novel bioactive compounds from actinomycetes, a phylogenetically novel strain, Streptomyces sp. TP-A0874, was isolated from a compost sample collected in Ishikawa, Japan, and found to produce a new catecholate derivative designated catechoserine, along with two known biosynthetically related metabolites, N,N=-bis(2,3-dihydroxybenzoyl)-O-L-seryl-L-serine and N,N=,N=-tris(2,3-dihydroxybenzoyl)-O-L-seryl-O-L-seryl-L-serine.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
