Abstract
We report the draft genome sequence of Streptomyces sp. TP-A0874 isolated from compost. This strain produces catechoserine, a new catecholate-type inhibitor of tumor cell invasion. The genome harbors at least six gene clusters for polyketide and nonribosomal peptide biosyntheses. The biosynthetic gene cluster for catechoserines was identified by bioinformatic analysis.
Highlights
We report the draft genome sequence of Streptomyces sp
TP-A0874, was isolated from a compost sample collected in Ishikawa, Japan, and found to produce a new catecholate derivative designated catechoserine, along with two known biosynthetically related metabolites, N,N=-bis(2,3-dihydroxybenzoyl)-O-L-seryl-L-serine and N,N=,N=-tris(2,3-dihydroxybenzoyl)-O-L-seryl-O-L-seryl-L-serine
To identify the biosynthetic gene cluster for these compounds and assess the potential to produce other secondary metabolites, we sequenced the genome of Streptomyces sp
Summary
We report the draft genome sequence of Streptomyces sp. TP-A0874 isolated from compost. In our search for novel bioactive compounds from actinomycetes, a phylogenetically novel strain, Streptomyces sp. TP-A0874, was isolated from a compost sample collected in Ishikawa, Japan, and found to produce a new catecholate derivative designated catechoserine, along with two known biosynthetically related metabolites, N,N=-bis(2,3-dihydroxybenzoyl)-O-L-seryl-L-serine and N,N=,N=-tris(2,3-dihydroxybenzoyl)-O-L-seryl-O-L-seryl-L-serine.
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