Abstract
Here, we report the draft genome sequence of Streptomyces sp. TP-A0356, a producer of a potent antitumor antibiotic, yatakemycin, to evaluate potential for secondary metabolite production. The genome sequence data suggest the presence of at least nine gene clusters for polyketide synthases and nonribosomal peptide synthetases in this strain.
Highlights
We report the draft genome sequence of Streptomyces sp
TP-A0356 was subjected to the whole-genome shotgun sequencing to survey polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) genes
TP-A0356 was deposited to the NBRC culture collection (NBRC 110464)
Summary
We report the draft genome sequence of Streptomyces sp. TP-A0356, a producer of a potent antitumor antibiotic, yatakemycin, to evaluate potential for secondary metabolite production. The complete sequence of the yatakemycin biosynthetic gene cluster and the biosynthetic pathway has been reported [3]. As a part of our screening for novel secondary metabolites through a genome mining approach [4], the yatakemycin-producer Streptomyces sp. TP-A0356 was subjected to the whole-genome shotgun sequencing to survey polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) genes.
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