Abstract
Fusobacterium necrophorum is a Gram-negative anaerobic bacterium that causes foot rot and liver abscesses in cattle. F. necrophorum subsp. necrophorum and the less virulent organism F. necrophorum subsp. funduliforme are recognized. We present here a draft genome sequence of the bovine liver abscess isolate F. necrophorum subsp. funduliforme strain B35, which affords a genomic perspective of virulence and bovine adaptation.
Highlights
Fusobacterium necrophorum is a Gram-negative anaerobic bacterium that causes foot rot and liver abscesses in cattle
F. necrophorum subsp. funduliforme-like organisms are associated with Lemierre’s syndrome, a syndrome characterized by suppurative thrombophlebitis of the internal jugular vein, bacteremia, and metastatic abscesses [3, 4]
Draft genome sequences have been determined for four human origin F. necrophorum subsp. funduliforme isolates, but none are available for any bovine F. necrophorum isolate
Summary
Fusobacterium necrophorum is a Gram-negative anaerobic bacterium that causes foot rot and liver abscesses in cattle. Necrophorum (formerly F. necrophorum biotype A) is the principal pathogen of cattle (causing liver abscesses, foot rot, and calf diphtheria), whereas F. necrophorum subsp. Funduliforme (biotype B), when isolated from liver abscesses, is more commonly recovered in mixed culture. Funduliforme is generally considered to be less virulent in the bovine host [2]. The subspecies differ in a number of characteristics [1], but these have not been delineated at the genomic level.
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