Abstract
A study was initiated to define the basal state of gene expression in the mouse liver prior to an investigation of responses during stress. It was found that: 1. 1. The ability of isolated mouse liver chromatin to be transcribed in vitro is increased when the chromatin is taken during hours of darkness rather than during the day. It is suggested that this night-time increase in template activity is related to the rhythmic pattern in other phenomena of gene expression in the rodent liver. 2. 2. The magnitude of the periodic increase in template activity is diminished in the adrenalectomized animal, suggesting the involvement of glucocorticoid secretion. 3. 3. The extent of the nocturnal rise in activity is not affected by starvation of the mice. A simple hepatic response to periodic ingestion of the diet appears to be an unlikely source of rhythmicity.
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