Abstract
This chapter explains whether dialyzable leukocyte extracts (DLEs) are able to reverse the E-rosetting capacity of theophylline treated lymphocytes (LTHs). In a study described in the chapter, DLEs were prepared from peripheral blood lymphocytes from unselected, HBs free, healthy young adults. LTHs came from 92 individuals, either healthy controls, lung-cancer patients, chronic bronchitis patients, or bussed patients. LTH were treated with theophylline. Treatment of lymphocytes with theophylline decreases the ability to form E rosette from 55% to 28%. DLEs must be at optimal concentration to express the ability to increase E-rosette capacity in TLH. Such E-rosetting restoration by DIE depends on individuals. This is probably related to individual variation in T-lymphocytes subpopulations, which different sensibility to theophylline treatment. E-rosetting restoration obtained in absence of any antigen is certainly different of that obtained by Agbata and Kirkpatrick with E–RAF obtained from antigen or mitogen stimulated lymphocytes.
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