Diagnostic Value of Imaging Combined With Tumor Markers in Early Detection of Lung Cancer.

Su-Ju Wei,Jun-Yan Wang,Yu-Dong Zhang,Feng-Bin Chuan,Jing-Xu Ma,Li-Ping Wang

doi:10.3389/fsurg.2021.694210

Abstract

Objective: The objective of this research is to explore the diagnostic value of imaging plus tumor markers in the early detection of lung cancer.Methods: Sixty patients with lung cancer treated in our hospital from January 2018 to January 2019 were selected as group A. They were matched with 60 patients with benign lung disease as group B and 60 healthy subjects examined in our hospital as group C. The carcino-embryonic antigen (CEA), CYFRA21-1, and neuron-specific enolase (NSE) were assessed, and the diagnostic value of tumor markers plus imaging in lung cancer diagnosis was explored.Results: The CEA, CYFRA21-1, and NSE in group A were evidently superior to those in groups B and C, and those in group B were superior to those in group C (all P < 0.001). CEA had the highest sensitivity (56.7%), and NSE had the highest specificity (93.3%). The tumor markers plus imaging had the highest sensitivity for different types of lung cancer, and the sensitivity to early lung cancer (90%) was superior to other diagnostic methods (P < 0.05).Conclusion: The tumor markers plus imaging is of great significance in early lung cancer diagnosis and provides a reference for judging the pathological classification.

Highlights

Lung cancer, one of the most lethal malignancies in clinical practice, lacks the specificity of early symptoms, resulting in difficulty in diagnosis
The receiver operating characteristic (ROC) curve was used to determine the area under curve (AUC); P < 0.05 indicated the statistical difference
The imaging diagnosis combined with tumor markers had the highest sensitivity of different types of lung cancer, and the sensitivity to lung cancer (90%) was superior to other diagnostic methods (P < 0.05), as shown in Tables 3, 4 and Figure 3

Summary

Introduction

One of the most lethal malignancies in clinical practice, lacks the specificity of early symptoms, resulting in difficulty in diagnosis. The development of an early diagnostic approach of lung cancer to improve the survival rate is highly desirable. As one of the routine detection methods for lung cancer, tumor markers are convenient and easy to obtain but with poor sensitivity. It is necessary to combine multiple tumor markers together to improve the diagnosis rate. With the development of multi-slice spiral CT technology, it has been widely used in practice. With the merit of being clear, simple, and efficient, it has played a certain positive role in early lung cancer diagnosis [1,2,3,4]. Studies that are concerned about the combination with CT and tumor markers

Methods

Results

Conclusion