Significance of combined detection of serum DcR3, CEA, CYFRA21-1 and NSE in diagnosis of primary lung cancer

Abstract

Objective To explore the significance of combined detection of serum decoy receptor 3(DcR3), carcinoembryonic antigen(CEA), cytokeratin 19 fragment (CYFRA21-1) and neuron specific enolase (NSE) in diagnosis of primary lung cancer. Methods 104 patients with lung cancer treated in the First Affiliated Hospital of Nanjing Medical University from March 2015 to June 2016 were selected as the lung cancer group, 66 patients with benign lung diseases were selected as the benign lesion group, and 40 healthy persons examined in the same period in our hospital were selected as the normal control group.The levels of DcR3, CEA, CYFRA21-1 and NSE in serum were examined by electro-chemiluminescence immunoassay and enzyme linked immunosorbent assay.Diagnostic effects of whole, different pathological types and different stages of lung cancer, combined and single diagnostic effects were contrasted. Results The levels of serum DcR3, CEA, CYFRA21-1 and NSE in lung cancer group were significantly higher than those in normal control group and benign lesion group (all P<0.05). The levels of DcR3 and NSE in serum of patients with small cell carcinoma were significantly higher than those of patients with adenocarcinoma and squamous cell carcinoma (all P<0.05). The level of CEA in serum of patients with small cell carcinoma was significantly lower than that of patients with adenocarcinoma and squamous cell carcinoma (all P<0.05). The overall diagnostic accuracy of CEA was 74.28%, and diagnostic efficiency of CYFRA21-1 was the highest (75.68%) in squamous cell carcinoma.The overall diagnostic accuracy of combined detection was significantly higher than that of single detection, and the specificity was lower than that of single detection (all P<0.05). Conclusions Combined detection of serum DcR3, CEA, CYFRA21-1 and NSE can obviously improve the diagnostic accuracy of lung cancer, and at the same time, it has a certain effect on different types of lung cancer. Key words: Decoy receptor 3; Carcinoembryonic antigen; Cytokeratin 19 fragment; Neuron specific enolase