The value of joint detection of tumor markers in the clinical diagnosis of lung cancer

Abstract

Objective To investigate the value of detection of 6 tumor markers: neuronspecific enolase(NSE), cytokeratin fragment 21-1(CYFRA21-1), carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA), Tumor Specific Growth Factor(TSGF) and squamous cell carcinoma antigen(SCC) in the clinical diagnosis of lung cancer. Methods From July 2013 to July 2014, 174 blood samples were collected from 76 lung cancer patients, 50 lung benign disease patients and 48 healthy controls.All the blood sample were detected for 6 tumor markers mentioned above by Immune chemiluminescence technique. Results Lung cancer patients have higher levels of 6 tumor markers than healthy controls(P<0.005) and have higher levels of 5 tumor markers except CA125 than patients with benign lung diseases(P<0.05). Among lung cancer patients, levels of 6 tumor markers were compared by 3 types of lung cancer as lung squamous cell carcinoma, lung adenocarcinoma and small cell carcinoma. Patients with lung squamous cell carcinoma have higher levels of SCC and CYFRA21-1 than patients with other two types(P<0.05, P<0.01). Patients with lung adenocarcinoma have higher levels of CA125 and CEA than patients with other two types (both P<0.01). Patients with small cell carcinoma had the highest level of NSE(P<0.05). No significant differences of TSGF level were observed among the 3 types of lung cancer. Conclusion The combined detection of multiple tumor markers is very useful in the diagnosis of lung cancer and in the pathologic classification and better than single assay. Key words: Lung cancer; Tumor marker