Abstract
Background: Endometrial cancer is the most common gynecological malignancy in postmenopausal women, often presenting with postmenopausal hemorrhage. Traditional diagnostic methods are invasive, prompting the need for less intrusive, accurate alternatives. Objective: To evaluate the efficacy of Doppler ultrasonography in diagnosing endometrial cancer in postmenopausal women presenting with hemorrhage, using histopathology as the gold standard. Methods: This cross-sectional study was conducted at the University of Lahore Teaching Hospital from September 2023 to March 2024, involving 140 postmenopausal women. Participants underwent transvaginal and transabdominal ultrasonography, including color and spectral Doppler assessments. Doppler findings were compared with histopathological outcomes following biopsy. Results: Doppler ultrasonography demonstrated a sensitivity of 78.63%, specificity of 65.22%, positive predictive value of 92.00%, negative predictive value of 37.50%, and overall diagnostic accuracy of 76.43%. Stratification analysis further indicated that the accuracy exceeded 90% in detecting endometrial cancer. Conclusion: Doppler ultrasonography is a valuable non-invasive diagnostic tool for detecting endometrial cancer in postmenopausal women with hemorrhage. It offers high sensitivity and specificity, reducing the necessity for invasive diagnostic procedures.
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