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Abstract
A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite–modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential in the redox process of MT, indicating the great enhancement of electrocatalytic activity toward the oxidation of MT by the composite of GNs and HA. Under the optimized conditions, the oxidation peak currents were related linearly with the concentration of MT, ranging from 2 μM to 3 mM, and the detection limit (S/N = 3) was 1.2 μM. In addition, the proposed electrochemical sensor can be successfully applied in the quantitative determination of MT in Sophora flavescens extract.
Highlights
Traditional Chinese medicine (TCM), with a long history in China, has gained popularity throughout the world with successful application in clinical treatments for many diseases due to its extensive functions [1,2,3,4]
As shown from the SEM image of graphene sheets that were synthesized by the reduction of graphene oxide (Figure 1A), a wrinkled-paper–like morphology was observed
The results indicated that 20-fold of Zn, Cu SO4, glucose, sucrose and glucose, ascorbic sucrose acid and and amylum, ascorbic acid no and uric acid had almost no influence on the amylum, uric acid had almost influence on the determination, and the tolerance determination, and the tolerance was to be less than 7% of the relative error
Summary
Traditional Chinese medicine (TCM), with a long history in China, has gained popularity throughout the world with successful application in clinical treatments for many diseases due to its extensive functions [1,2,3,4]. The herbs containing MT can be taken orally or used extensively in the synthesis of traditional Chinese medicine as well, and they are effective in the clinical treatment of various diseases such as hepatitis, acute dysentery, acute pharyngolaryngitis, eczema, gastrointestinal hemorrhage and colitis. Considering the significant pharmacological activities and extensive clinical applications of MT, developing a simple, rapid and highly sensitive method for the determination of MT of different contents in herbs is highly demanded for its medicinal preparations. Miao [22] investigated the Molecules 2017, 22, 575; doi:10.3390/molecules22040575 www.mdpi.com/journal/molecules
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