Determination of trace metformin in pharmaceutical preparation using molecularly imprinted polymer based pvc-membrane

Abstract

Polymerization of precipitation was used to make liquid electrodes with metformin (MET) imprinted polymers. lev was used as a template to make molecular (MIP) and non-imprinted (NIP) polymers. In the polymerization process, methyl methacrylate (MMA), acrylamide (AM), ethylene glycol dimethacrylate (EGDMA), and benzoyl peroxide (BPO) were employed as monomers, cross-linkers, and initiators. Using Di B Sabacat (DBS) and Di methyl adipate (DMA) as plasticizers in PVC matrix, the molecularly imprinted membranes and the non- membranes were prepared. The liquid electrodes' slopes and detection limits were -28.03 – -19.45 mV/decade and 3×10-5 M–7×10-5 M, respectively, and their reaction time was about 1 minute. Liquid electrodes were filled with 0.1 M standard drug solution, and their response was consistent throughout a pH range of 1.5 to 10.0, with high selectivity for several types. The electrodes developed have been effectively used in the production of pharmaceutical samples for analyte analysis without the need for time-consuming pretreatment.